Ontology highlight
ABSTRACT:
SUBMITTER: Liu SY
PROVIDER: S-EPMC8575965 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Liu Si-Yang SY Bao Hua H Wang Qun Q Mao Wei-Min WM Chen Yedan Y Tong Xiaoling X Xu Song-Tao ST Wu Lin L Wei Yu-Cheng YC Liu Yong-Yu YY Chen Chun C Cheng Ying Y Yin Rong R Yang Fan F Ren Sheng-Xiang SX Li Xiao-Fei XF Li Jian J Huang Cheng C Liu Zhi-Dong ZD Xu Shun S Chen Ke-Neng KN Xu Shi-Dong SD Liu Lun-Xu LX Yu Ping P Wang Bu-Hai BH Ma Hai-Tao HT Yan Hong-Hong HH Dong Song S Zhang Xu-Chao XC Su Jian J Yang Jin-Ji JJ Yang Xue-Ning XN Zhou Qing Q Wu Xue X Shao Yang Y Zhong Wen-Zhao WZ Wu Yi-Long YL
Nature communications 20211108 1
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II-IIIA non-small cell lung cancer (NSCLC). However, not all patients experienced favorable clinical outcomes with tyrosine kinase inhibitors (TKI), raising the necessity for further biomarker assessment. In this work, by comprehensive genomic profiling of 171 tumor tissues from the ADJUVANT trial, five predictive biomarkers are identified (TP53 e ...[more]