Silica particles with fluorescein-labelled cores for evaluating accessibility through fluorescence quenching by copper.

ABSTRACT: Core-shell particles with fluorescent cores were synthesised by growing silica shells on fluorescein-labelled Stöber-type particles. The porosity of the shell could be altered in a subsequent pseudomorphic transformation step, without affecting the particle size and shape. These core-shell particles constitute a platform for the evaluation of pore connectivity and core accessibility by observing the effect of a quencher on the fluorescence signal emitted by the fluorescein-labelled cores. In combination with argon sorption measurements, quenching experiments with copper provided valuable information on the porosity generated during the shell formation process. It was further observed that the introduction of well-defined mesopores by pseudomorphic transformation in the presence of a struct

SUBMITTER: Gallagher SH 

PROVIDER: S-EPMC8577346 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature