Relative Efficacy and Safety of Tanezumab for Osteoarthritis: A Systematic Review and Meta-analysis of Randomized-Controlled Trials.

ABSTRACT:

Objectives

The aim of this meta-analysis was to evaluate the efficacy and safety of tanezumab for the treatment of patients with knee or hip osteoarthritis (OA).

Methods

PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched from inception to July 2020. Randomized-controlled trials comparing tanezumab with placebo or nonsteroidal anti-inflammatory drugs in patients with OA. Two investigators identified studies and independently extracted data, and conventional meta-analyses were conducted with Review Manager 5.3. The outcomes were pain relief, functional improvement, and risk of adverse events (AEs).

Results

A total of 8 articles, comprising 9 randomized-controlled trials, were included. Overall, tanezumab was superior to plac

SUBMITTER: Zhang B 

PROVIDER: S-EPMC8579990 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature