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Influence of the primary and secondary coordination spheres on nitric oxide adsorption and reactivity in cobalt(ii)-triazolate frameworks.

ABSTRACT: Nitric oxide (NO) is an important signaling molecule in biological systems, and as such, the ability of porous materials to reversibly adsorb NO is of interest for potential medical applications. Although certain metal-organic frameworks are known to bind NO reversibly at coordinatively unsaturated metal sites, the influence of the metal coordination environment on NO adsorption has not been studied in detail. Here, we examine NO adsorption in the frameworks Co₂Cl₂(bbta) (H₂bbta = 1H,5H-benzo(1,2-d:4,5-d')bistriazole) and Co₂(OH)₂(bbta) using gas adsorption, infrared spectroscopy, powder X-ray diffraction, and magnetometry. At room temperature, NO adsorbs reversibly in Co₂Cl₂(bbta) without electron transfer, with low temperature data supporting spin-crossover of the NO-bound cobalt(ii) centers of the material. In contrast, adsorption of low pressures of NO in Co₂(OH)₂(bbta) is accompanied by charge transfer from the cobalt(ii) centers to form a cobalt(iii)-NO^- adduct, as supported by diffraction and infrared spectroscopy data. At higher pressures of NO, characterization data indicate additional uptake of the gas and disproportionation of the bound NO to form a cobalt(iii)-nitro (NO₂ ^-) species and N₂O gas, a transformation that appears to be facilitated by secondary sphere hydrogen bonding interactions between the bound NO₂ ^- and framework hydroxo groups. These results provide a rare example of reductive NO binding in a cobalt-based metal-organic framework, and they demonstrate that NO uptake can be tuned by changing the primary and secondary coordination environment of the framework metal centers.

SUBMITTER: Oktawiec J

PROVIDER: S-EPMC8580060 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Cu-BTTri (H3BTTri = 1,3,5-tris[1H-1,2,3-triazol-5-yl]benzene) is a water-stable, copper-based metal-organic framework (MOF) that exhibits the ability to generate therapeutic nitric oxide (NO) from S-nitrosothiols (RSNOs) available within the bloodstream. Immobilization of Cu-BTTri within a polymeric membrane may allow for localized NO generation at the blood-material interface. This work demonstrates that Cu-BTTri can be incorporated within hydrophilic membranes prepared from poly(vinyl alcohol) (PVA), a polymer that has been examined for numerous biomedical applications. Following immobilization, the ability of the MOF to produce NO from the endogenous RSNO S-nitrosoglutathione (GSNO) is not significantly inhibited. Poly(vinyl alcohol) membranes containing dispersions of Cu-BTTri were tested for their ability to promote NO release from a 10 ?M initial GSNO concentration at pH 7.4 and 37 °C, and NO production was observed at levels associated with antithrombotic therapeutic effects without significant copper leaching (<1%). Over 3.5 ± 0.4 h, 10 wt % Cu-BTTri/PVA membranes converted 97 ± 6% of GSNO into NO, with a maximum NO flux of 0.20 ± 0.02 nmol·cm-2·min-1. Furthermore, it was observed for the first time that Cu-BTTri is capable of inducing NO production from GSNO under aerobic conditions. At pH 6.0, the NO-forming reaction of 10 wt % Cu-BTTri/PVA membrane was accelerated by 22%, while an opposite effect was observed in the case of aqueous copper(II) chloride. Reduced temperature (20 °C) and the presence of the thiol-blocking reagent N-ethylmaleimide (NEM) impair the NO-forming reaction of Cu-BTTri/PVA with GSNO, with both conditions resulting in a decreased NO yield of 16 ± 1% over 3.5 h. Collectively, these findings suggest that Cu-BTTri/PVA membranes may have therapeutic utility through their ability to generate NO from endogenous substrates. Moreover, this work provides a more comprehensive analysis of the parameters that influence Cu-BTTri efficacy, permitting optimization for potential medical applications.

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Influence of the primary and secondary coordination spheres on nitric oxide adsorption and reactivity in cobalt(ii)-triazolate frameworks.

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