Evaluation of seven gene signature for predicting HCV recurrence post-liver transplantation.

ABSTRACT:

Background

Orthotropic liver transplantation (OLT) offers a therapeutic choice for hepatocellular carcinoma (HCC) patients. The poor outcome of liver transplantation is HCV recurrence. Several genome-wide associated studies (GWAS) have reported many genetic variants to be associated with HCV recurrence. Seven gene polymorphisms formed a cirrhosis risk score (CRS) signature that could be used to distinguish chronic HCV patients at high risk from those at low risk for cirrhosis in non-transplant patients. This study aims to examine the association of CRS score and other clinical parameters with the probability for HCC emergence and/or the rate of HCV recurrence following liver transplantation.

Results

Seven gene polymorphisms, forming the CRS, were genotyped by real-time PCR u

SUBMITTER: Salum GM 

PROVIDER: S-EPMC8581076 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature