Ontology highlight
ABSTRACT:
SUBMITTER: Wan YJ
PROVIDER: S-EPMC85811 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
Wan Y J YJ An D D Cai Y Y Repa J J JJ Hung-Po Chen T T Flores M M Postic C C Magnuson M A MA Chen J J Chien K R KR French S S Mangelsdorf D J DJ Sucov H M HM
Molecular and cellular biology 20000601 12
A large number of physiological processes in the adult liver are regulated by nuclear receptors that require heterodimerization with retinoid X receptors (RXRs). In this study, we have used cre-mediated recombination to disrupt the mouse RXRalpha gene specifically in hepatocytes. Although such mice are viable, molecular and biochemical parameters indicate that every one of the examined metabolic pathways in the liver (mediated by RXR heterodimerization with PPARalpha, CARbeta, PXR, LXR, and FXR) ...[more]