Effects of Carbidopa Premedication on ¹⁸F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis.

ABSTRACT:

Purpose

This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of ¹⁸F-FDOPA PET in brain tumors.

Methods

The study included 54 patients, 18 of whom received carbidopa, who underwent ¹⁸F-FDOPA PET for newly diagnosed gliomas. SUV-derived, 105 radiomics features and TTP dynamic parameters were extracted from volumes of interest in healthy brains and tumors. Simulation of the effects of carbidopa on time-activity curves were generated.

Results

All static and TTP dynamic parameters were significantly higher in healthy brain regions of premedicated patients (ΔSUV_mean = +53%, ΔTTP = +48%, p < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correla

SUBMITTER: Bros M 

PROVIDER: S-EPMC8582429 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature