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Effects of probiotic supplementation on respiratory infection and immune function in athletes: systematic review and meta-analysis of randomized controlled trials.

ABSTRACT: The aim of this study was to evaluate the effectiveness of probiotic supplementation on upper tract respiratory infection and inflammatory markers in elite athletes. We identified sources by searching the PubMed, EBSCO host, Scopus, and Web of Science databases using the following search terms: "probiotic" OR "probiotics" AND "exercise" OR "sport" OR "athletes" AND "URTI" OR "respiratory infection" OR "upper respiratory tract infections" OR "inflammation" OR "inflammatory OR "cytokines". We screened the title and abstracts of 2498 articles using our inclusion critieria. A total of 14 articles were selected for further analysis. Data from the included studies were extracted by 2 independent reviewers. These data included the study design, participant characteristics, inclusion and exclusion, intervention characteristics, outcome measures, and the main results of the study. The meta-analysis did not show any significant effect of probiotic supplementation on the number of days of illness or the mean number and duration of URTI episodes, but there was a significant effect of probiotic supplementation on total symptom severity score (-0.65, 95% CI: -1.05; -0.25, p = 0.02). Lower levels of IL-6 (-2.52 pg/ml, 95% CI: -4.12, -0.51, p = 0.001) and TNF-α (-2.31 pg/ml, 95% CI: -4.12, -0.51, p = 0.008) were also reported after supplementation. This meta-analysis provides evidence that probiotic supplementation, especially among professional athletes, is an effective way to decrease the total URTI symptom severity score. Additionally, probiotic supplementation may decrease TNF-α and IL-6 levels. There is a need for more studies with larger groups to better estimate this effect. It is necessary to determine the best timing, duration, composition and dose of such supplementation.

SUBMITTER: Lagowska K

PROVIDER: S-EPMC8582629 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Probiotic Supplementation and Respiratory Infection and Immune Function in Athletes: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Łagowska Karolina K Bajerska Joanna J

Journal of athletic training 20211101 11

<h4>Objective</h4>To evaluate the effectiveness of probiotic supplementation on upper respiratory tract infection (URTI) and inflammatory markers in elite athletes.<h4>Data sources</h4>We searched the PubMed, EBSCOhost, Scopus, and Web of Science databases using the following terms: probiotic OR probiotics AND exercise OR sport OR athletes AND URTI OR respiratory infection OR URTIs OR inflammation OR inflammatory OR cytokines.<h4>Study selection</h4>We screened the titles and abstracts of 2498 a ...[more]

PMID: 33481001

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Project description:BackgroundSome probiotics appear to improve athletic performance, endurance, and recovery after intense exercise. Other formulations may provide performance-related benefits via immune and gastrointestinal functions in athletic individuals. However, few formulations have been studied for both types of effects among non-elite athletes. The primary objective of this study is to assess the ergogenic effects of a probiotic on high-intensity endurance running performance in non-elite runners. Secondary objectives include assessment of perceived exertion, blood chemistry, immune and stress biomarkers, cold and flu symptoms, and gastrointestinal health after the probiotic intervention.MethodsThis 9-week randomized, placebo-controlled, double-blind, parallel trial will assess the ergogenic effects of a probiotic (5 billion colony-forming units/day, for 6 weeks) in healthy, non-elite runners (N=32; 18-45 years). Participants will be monitored via daily and weekly questionnaires during the 2-week pre-baseline, 6-week intervention, and 1-week washout. Questionnaires will inquire about activity, muscle soreness, gastrointestinal symptoms, cold and flu symptoms, stool form and frequency, and adverse events. During the pre-baseline visit, maximal oxygen uptake (V̇O2 max) is assessed to set appropriate individualized workload settings for the treadmill time-to-exhaustion endurance tests. These time-to-exhaustion endurance running tests will be completed at an intensity of 85% VO2max at baseline and final visits. During these tests, self-perceived exercise effort will be rated via the Borg Rating of Perceived Exertion scale and finger sticks assessing capillary blood glucose and lactate concentrations will be collected every 3 min. Additional questionnaires will assess diet and motivation to exercise. Body composition will be assessed using air displacement plethysmography at the baseline and final visits. Hypotheses will be tested using two-sided tests, and a linear model and with a type I error rate of α=0.05. Primary and secondary outcomes will be tested by comparing results between the intervention groups, adjusting for baseline values.DiscussionThese results will build evidence documenting the role of probiotics on running endurance performance and physiological responses to exercise in non-elite athletes. Understanding the potential mechanisms of probiotic effects and how they mitigate the intestinal or immune discomforts caused by running could provide additional strategy means to help runners improve their performance.Trial registration numberClinicalTrials.gov NCT04588142 . Posted on October 19, 2020.Protocol versionJuly 2, 2021, version 1.2.

Project description:BackgroundGastrointestinal (GI) problems represent a health burden in Para athletes and can ultimately reduce athletic performance. This study aimed to evaluate the feasibility of a randomized controlled crossover trial (RCCT) assessing the effects of probiotic and prebiotic supplementation on the health of Swiss elite wheelchair athletes.MethodsThe RCCT was conducted between March 2021 and October 2021. Athletes were randomized to receive either a daily probiotic (3 g of probiotic preparation, including eight bacterial strains), or a daily prebiotic (5 g of oat bran) supplementation first. After the first supplementation phase (4 weeks), a washout period (4 weeks) and the second crossover supplementation phase (4 weeks) followed. Data were collected at four study visits (every 4 weeks) and included 3-day training and nutrition diaries, the Gastrointestinal Quality of Life Index (GIQLI) questionnaire, stool samples, and fasting blood samples. The study assessed the feasibility criteria such as recruitment rate, retention rate, success of data collection, adherence to the protocol, willingness to participate, and safety.ResultsThis pilot study met the majority of the predefined minimum requirements for the feasibility criteria. Out of 43 invited elite wheelchair athletes, 14 (33%) consented (mean (standard deviation) age: 34 (9) years, eight females, 11 with a spinal cord injury). The desired sample size was not reached, but the achieved recruitment rate was modest, especially considering the population studied. All participating athletes completed the study. With the exception of one missing stool sample and two missing diaries, data were successfully collected for all athletes at all four visits. Most athletes adhered to the daily intake protocol for at least 80% of the days, both for probiotics (n = 12, 86%) and prebiotics (n = 11, 79%). Ten (71%) athletes would be willing to participate in a similar study again. No serious adverse events occurred.ConclusionDespite the limited number of elite wheelchair athletes in Switzerland and the modest recruitment rate, the implementation of a RCCT in elite wheelchair athletes is feasible. The data collected in this study provide essential information for the design of the subsequent study which will include a larger cohort of physically active wheelchair users.Trial registrationSwiss Ethics Committee for Northwest/Central Switzerland (EKNZ), 2020-02337).Clinicaltrialsgov, NCT04659408.

Dataset Information

Effects of probiotic supplementation on respiratory infection and immune function in athletes: systematic review and meta-analysis of randomized controlled trials.

Publications

Probiotic Supplementation and Respiratory Infection and Immune Function in Athletes: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

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