Ontology highlight
ABSTRACT:
SUBMITTER: Schmitz W
PROVIDER: S-EPMC8583874 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Schmitz Werner W Ries Elena E Koderer Corinna C Völter Maximilian Friedrich MF Wünsch Anna Chiara AC El-Mesery Mohamed M Frackmann Kyra K Kübler Alexander Christian AC Linz Christian C Seher Axel A
International journal of molecular sciences 20211027 21
Methionine restriction (MetR) is an efficient method of amino acid restriction (AR) in cells and organisms that induces low energy metabolism (LEM) similar to caloric restriction (CR). The implementation of MetR as a therapy for cancer or other diseases is not simple since the elimination of a single amino acid in the diet is difficult. However, the in vivo turnover rate of cysteine is usually higher than the rate of intake through food. For this reason, every cell can enzymatically synthesize c ...[more]