The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers.

ABSTRACT:

Purpose

Remifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature of this observation.

Methods

We analysed samples from three pharmacokinetic studies to determine the serum concentrations of naloxone-3-glucuronide (N3G), the main metabolite of naloxone, with or without exposure to remifentanil. To enable direct comparison of the three studies, the data are presented as metabolic ratios (ratio of metabolite to mother substance, N3G/naloxone) and dose-corrected values of the area under the curve and maximum concentration (Cmax).

Results

Under remifentanil exposure, the time to maximum concentration (Tmax) for N3G was significantly higher for intranasal administration of 71 min compared t

SUBMITTER: Tylleskar I 

PROVIDER: S-EPMC8585821 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature