Ontology highlight
ABSTRACT:
SUBMITTER: Zhao XK
PROVIDER: S-EPMC8586158 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Zhao Xue-Ke XK Xing Pengwei P Song Xin X Zhao Miao M Zhao Linxuan L Dang Yonglong Y Lei Ling-Ling LL Xu Rui-Hua RH Han Wen-Li WL Wang Pan-Pan PP Yang Miao-Miao MM Hu Jing-Feng JF Zhong Kan K Zhou Fu-You FY Han Xue-Na XN Meng Chao-Long CL Ji Jia-Jia JJ Chen Xingqi X Wang Li-Dong LD
Nature communications 20211111 1
The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, we identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, and find focal amplifications in the GCA cohort are associated with the chromothripsis process and may be induced by accumulated DNA damage due to local dietary habits. We observe diverse correlations between the presence of oncogene focal amplifications and prognosis, where ERBB2 focal ampl ...[more]