Ontology highlight
ABSTRACT:
SUBMITTER: Chen YF
PROVIDER: S-EPMC8586549 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Chen Yun-Fu YF Yu Si-Fei SF Wu Chang-You CY Wu Na N Shen Jia J Shen Juan J Gao Jiang-Mei JM Wen Yan-Zi YZ Hide Geoff G Lai De-Hua DH Lun Zhao-Rong ZR
Frontiers in microbiology 20211029
<i>Leishmania</i> infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors. Inbred mouse strains vary in resistance to <i>Leishmania major</i> but are highly susceptible to <i>Leishmania amazonensis</i> infection. However, rats are highly resistant to <i>L. amazonensis</i> infection due to unknown mechanisms. We use the inducible nitric oxide synthase (<i>Nos2)</i> gene knockout rat model (<i>Nos2</i> <sup ...[more]