Innate Resistance to Leishmania amazonensis Infection in Rat Is Dependent on NOS2.

ABSTRACT: Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors. Inbred mouse strains vary in resistance to Leishmania major but are highly susceptible to Leishmania amazonensis infection. However, rats are highly resistant to L. amazonensis infection due to unknown mechanisms. We use the inducible nitric oxide synthase (Nos2) gene knockout rat model (Nos2 ^-/- rat) to investigate the role of NOS2 against leishmania infection in rats. Our results demonstrated that diversion toward the NOS2 pathway is the key factor explaining the resistance of rats against L. amazonensis infection. Rats deficient in NOS2 are susceptible to L. amazonens

SUBMITTER: Chen YF 

PROVIDER: S-EPMC8586549 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature