Ontology highlight
ABSTRACT: Background
A total of 62/66 (93.9%) residents in a senior citizen home in Bremen, Germany, received the first dose of the Biontech/Pfizer vaccine BNT162b2 on December 27th 2020. After routine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests showed positive results on January 5th, all residents and staff were tested by RT-PCR.Results
Nine staff members and 23 residents had a positive result. PCR positive staff members reported mild to severe COVID-19 symptoms, one was hospitalized. None of them had been vaccinated. In contrast, the vaccinated residents reported no or only mild symptoms. Sequencing of the SARS-CoV-2 genomes of infected individuals revealed a monophyletic origin of the outbreak within the PANGO lineage B.1.177.86.Conclusions
In summary, our data show that partial vaccination prevented severe COVID-19 among the residents during this local SARS-CoV-2 outbreak, suggesting a high effectiveness of even a single vaccine dose, but also emphasize that asymptomatic individuals might still be carriers/spreaders.
SUBMITTER: Schwarzer R
PROVIDER: S-EPMC8589371 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Schwarzer Rolf R Freys Sabine D SD Neuwinger Nick N Beikert Nina N Eberspächer Bettina B Edelmann Anke A Zuchowski Marta M Slothouwer Inga I Stein Angela A Theil Kathrin K Menzel Peter P Hofmann Jörg J
Immunity, inflammation and disease 20210916 4
<h4>Background</h4>A total of 62/66 (93.9%) residents in a senior citizen home in Bremen, Germany, received the first dose of the Biontech/Pfizer vaccine BNT162b2 on December 27th 2020. After routine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests showed positive results on January 5th, all residents and staff were tested by RT-PCR.<h4>Results</h4>Nine staff members and 23 residents had a positive result. PCR positive staff members reported mild to severe COVID-19 symp ...[more]