The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury.

ABSTRACT:

Introduction

Tranexamic acid (TXA) has shown to be beneficial in selected patients with hemorrhagic shock. Recently, TXA has gained interest in isolated traumatic brain injury (TBI) patients with variable results. There are limited data on TXA in polytrauma with associated TBI. This study investigated the role of TXA in severely injured patients with associated severe TBI.

Methods

A 7.5-year prospective cohort study was performed to investigate the relation between prehospital TXA and mortality in consecutive trauma patients with associated severe TBI (Abbreviated Injury Scale (AIS)head ≥ 3) admitted to a Level-1 Trauma Center ICU. Indication for prehospital TXA administration was (suspicion of) hemorrhagic shock, and/or systolic blood pressure (SBP) ≤ 90 mmHg. Demographics,

SUBMITTER: van Wessem KJP 

PROVIDER: S-EPMC8590807 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature