Characterization of the Immune Cell Infiltration Landscape of Thyroid Cancer for Improved Immunotherapy.

ABSTRACT: Within the endocrine system, thyroid cancer (THCA) is the most typical malignant tumor. Tumor-infiltrating immune cells play vital roles in tumor progression, recurrence, metastasis as well as response to immunotherapy. However, THCA's immune infiltrative landscape is still not clarified. Therefore, we utilized two statistical algorithms to investigate the immune cell infiltration (ICI) landscape of 505 THCA samples and defined three ICI immune subtypes. The ICI scores were calculated using principal-component analysis. Increased tumor mutation burden (TMB) and immune-related signaling pathways were associated to a high ICI score. The high ICI score group indicated a relatively longer overall survival (OS) than the low ICI score group. Most immune checkpoint-related and immune activation-r

SUBMITTER: Gong J 

PROVIDER: S-EPMC8591054 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature