Role of DBP in the circadian oscillatory mechanism.
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ABSTRACT:
SUBMITTER: Yamaguchi S
PROVIDER: S-EPMC85912 | biostudies-literature | 2000 Jul
REPOSITORIES: biostudies-literature
Publications
Role of DBP in the circadian oscillatory mechanism.
Yamaguchi S S Mitsui S S Yan L L Yagita K K Miyake S S Okamura H H
Molecular and cellular biology 20000701 13
Transcript levels of DBP, a member of the PAR leucine zipper transcription factor family, exhibit a robust rhythm in suprachiasmatic nuclei, the mammalian circadian center. Here we report that DBP is able to activate the promoter of a putative clock oscillating gene, mPer1, by directly binding to the mPer1 promoter. The mPer1 promoter is cooperatively activated by DBP and CLOCK-BMAL1. On the other hand, dbp transcription is activated by CLOCK-BMAL1 through E-boxes and inhibited by the mPER and m ...[more]
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