Modulatory role of atorvastatin against high-fat diet and zymosan-induced activation of TLR2/NF-ƙB signaling pathway in C57BL/6 mice.

ABSTRACT:

Objectives

Accumulated evidence provides a strong connection between the immune system and vascular inflammation. The innate immune system's main sensors are toll-like receptors (TLRs). Zymosan (Zym), a fungal product, induces an inflammatory response via activating TLR2 of the immune system. Atorvastatin, a potent statin, possesses pleiotropic effects including immunomodulatory, lipid-lowering, and anti-inflammatory. Therefore, the current study aimed to evaluate the protective role of atorvastatin against a high-fat diet (HFD) and Zym-induced vascular inflammation in C57BL/6 mice via modulation of TLR2/NF-ƙB signaling pathway.

Materials and methods

In silico study was conducted to confirm the binding affinity of atorvastatin against TLR2. Under in vivo study,

SUBMITTER: Arya P 

PROVIDER: S-EPMC8591763 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature