Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish.

ABSTRACT:

Background

Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure. Naoxintong (NXT), as a traditional Chinese Medicine (TCM) preparation, is widely used in the treatment of cardiovascular diseases, including cardiomyopathy, while its underlying mechanism has not been fully elucidated. The purpose of this study is to investigate the therapeutic effect of NXT on cardiomyopathy and its molecular mechanism in zebrafish model.

Methods

The zebrafish cardiomyopathy model was established using terfenadine (TFD) and treated with NXT. The therapeutic effect of NXT on cardiomyopathy was evaluated by measuring the heart rate, the distance between the sinus venosus and

SUBMITTER: Hu M 

PROVIDER: S-EPMC8591872 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature