Dataset Information

Metaheuristics for pharmacometrics.

ABSTRACT: Metaheuristics is a powerful optimization tool that is increasingly used across disciplines to tackle general purpose optimization problems. Nature-inspired metaheuristic algorithms is a subclass of metaheuristic algorithms and have been shown to be particularly flexible and useful in solving complicated optimization problems in computer science and engineering. A common practice with metaheuristics is to hybridize it with another suitably chosen algorithm for enhanced performance. This paper reviews metaheuristic algorithms and demonstrates some of its utility in tackling pharmacometric problems. Specifically, we provide three applications using one of its most celebrated members, particle swarm optimization (PSO), and show that PSO can effectively estimate parameters in complicated nonlinear mixed-effects models and to gain insights into statistical identifiability issues in a complex compartment model. In the third application, we demonstrate how to hybridize PSO with sparse grid, which is an often-used technique to evaluate high dimensional integrals, to search for D -efficient designs for estimating parameters in nonlinear mixed-effects models with a count outcome. We also show the proposed hybrid algorithm outperforms its competitors when sparse grid is replaced by its competitor, adaptive gaussian quadrature to approximate the integral, or when PSO is replaced by three notable nature-inspired metaheuristic algorithms.

SUBMITTER: Kim S

PROVIDER: S-EPMC8592519 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Metaheuristics for pharmacometrics.

Kim Seongho S Hooker Andrew C AC Shi Yu Y Kim Grace Hyun J GHJ Wong Weng Kee WK

CPT: pharmacometrics & systems pharmacology 20211022 11

Metaheuristics is a powerful optimization tool that is increasingly used across disciplines to tackle general purpose optimization problems. Nature-inspired metaheuristic algorithms is a subclass of metaheuristic algorithms and have been shown to be particularly flexible and useful in solving complicated optimization problems in computer science and engineering. A common practice with metaheuristics is to hybridize it with another suitably chosen algorithm for enhanced performance. This paper re ...[more]

PMID: 34562342

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Project description:Electroencephalography (EEG) serves as a diagnostic technique for measuring brain waves and brain activity. Despite its precision in capturing brain electrical activity, certain factors like environmental influences during the test can affect the objectivity and accuracy of EEG interpretations. Challenges associated with interpretation, even with advanced techniques to minimize artifact influences, can significantly impact the accurate interpretation of EEG findings. To address this issue, artificial intelligence (AI) has been utilized in this study to analyze anomalies in EEG signals for epilepsy detection. Recurrent neural networks (RNNs) are AI techniques specifically designed to handle sequential data, making them well-suited for precise time-series tasks. While AI methods, including RNNs and artificial neural networks (ANNs), hold great promise, their effectiveness heavily relies on the initial values assigned to hyperparameters, which are crucial for their performance for concrete assignment. To tune RNN performance, the selection of hyperparameters is approached as a typical optimization problem, and metaheuristic algorithms are employed to further enhance the process. The modified hybrid sine cosine algorithm has been developed and used to further improve hyperparameter optimization. To facilitate testing, publicly available real-world EEG data is utilized. A dataset is constructed using captured data from healthy and archived data from patients confirmed to be affected by epilepsy, as well as data captured during an active seizure. Two experiments have been conducted using generated dataset. In the first experiment, models were tasked with the detection of anomalous EEG activity. The second experiment required models to segment normal, anomalous activity as well as detect occurrences of seizures from EEG data. Considering the modest sample size (one second of data, 158 data points) used for classification models demonstrated decent outcomes. Obtained outcomes are compared with those generated by other cutting-edge metaheuristics and rigid statistical validation, as well as results' interpretation is performed.

Dataset Information

Metaheuristics for pharmacometrics.

Publications

Metaheuristics for pharmacometrics.

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