Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1.
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ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC8593044 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
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Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1.
Li Shishi S Zhou Yier Y Huang Qiongxiao Q Fu Xiaohua X Zhang Ling L Gao Fang F Jin Zhen Z Wu Limei L Shu Chongyi C Zhang Xirong X Xu Weihai W Shu Jing J
Cell death discovery 20211115 1
Endometriosis is one of the most common disorders that causes infertility in women. Iron is overloaded in endometriosis peritoneal fluid (PF), with harmful effects on early embryo development. However, the mechanism by which endometriosis peritoneal fluid affects embryonic development remains unclear. Hence, this study investigated the effect of iron overload on mouse embryos and elucidated the molecular mechanism. Iron overload in endometriosis PF disrupted blastocyst formation, decreased GPX4 ...[more]
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