Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer.
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ABSTRACT: Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy.
SUBMITTER: Shapiro LC
PROVIDER: S-EPMC8595142 | biostudies-literature |
REPOSITORIES: biostudies-literature
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