Dataset Information
Gray and White Matter Correlates of Dysphagia in Progressive Supranuclear Palsy.
Ontology highlight
ABSTRACT: Background
Dysphagia is a common symptom of progressive supranuclear palsy often leading to aspiration pneumonia and death.Objective
The aim of this study was to examine how impairments of the oral and pharyngeal phases of the swallow and airway incursion during liquid swallows relate to gray and white matter integrity.Methods
Thirty-eight participants with progressive supranuclear palsy underwent videofluorographic swallowing assessment and structural and diffusion tensor head magnetic resonance imaging. Penalized linear regression models assessed relationships between swallowing metrics and regional gray matter volumes and white matter fractional anisotropy and mean diffusivity.Results
Oral phase impairments were associated with reduced superior parietal volumes and abnormal diffusivity in parietal and sensorimotor white matter, posterior limb of the internal capsule, and superior longitudinal fasciculus. Pharyngeal phase impairments were associated with disruption to medial frontal lobe, corticospinal tract, and cerebral peduncle. No regions were predictive of airway incursion.Conclusions
Differential patterns of neuroanatomical impairment corresponded to oral and pharyngeal phase swallowing impairments. © 2021 International Parkinson and Movement Disorder Society.
SUBMITTER: Clark HM
PROVIDER: S-EPMC8595517 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Gray and White Matter Correlates of Dysphagia in Progressive Supranuclear Palsy.
Movement disorders : official journal of the Movement Disorder Society 20210823 11
<h4>Background</h4>Dysphagia is a common symptom of progressive supranuclear palsy often leading to aspiration pneumonia and death.<h4>Objective</h4>The aim of this study was to examine how impairments of the oral and pharyngeal phases of the swallow and airway incursion during liquid swallows relate to gray and white matter integrity.<h4>Methods</h4>Thirty-eight participants with progressive supranuclear palsy underwent videofluorographic swallowing assessment and structural and diffusion tenso ...[more]