Ontology highlight
ABSTRACT:
SUBMITTER: Cai C
PROVIDER: S-EPMC8596812 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Cai Chenhui C Hu Wenhui W Zhang Ying Y Hu Xu X Yang Sizhen S Qiu Hao H Wang Rujie R Ma Min M Qiu Yiyun Y Chu Tongwei T
Frontiers in pharmacology 20211101
Osteoporosis is a common aging-related metabolic disease that mainly occurs in older adults and postmenopausal women. Despite advances in anti-osteoporosis treatment, outcomes remain unsatisfactory due to detrimental side effects. BCI hydrochloride (BCI), a selective dual-specificity phosphatase 6 (DUSP6) inhibitor, is associated with multiple cellular functions, including inhibiting tumor growth and macrophage inflammation; however, its role in regulating osteoclast differentiation remains unkn ...[more]