Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

ABSTRACT:

Background

Growing body of evidence suggest the association between SNP − 11377 C > G and SNP + 276 G > T polymorphisms of adiponectin gene with type 2 diabetes (T2D). However, these findings have not been conclusive and consistent. The present study quantitatively evaluates the data on the association between DIPOQ − 11377C/G, and + 276G/T polymorphisms and risk of T2D through a meta-analysis.

Methods

A systematic search was performed in the PubMed, Web of science, Scopus and Cochrane library databases to extract published studies according to the inclusion criteria. Among the 741 studies, 391 of them were screened as full text and 31 studies were finally included in the meta-analysis. Analysis of data was performed using random-effects model. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to analyze the strength of association. Subgroup and meta-regression analyses were performed to identify the potential source of heterogeneity.

Results

The pooled analysis showed that there was no statistically significant association between genotypes of CC (OR = 0.76, 95% CI: 0.53–1.09, P = 0.14), CG (OR = 0.93, 95% CI: 0.72–1.20, P = 0.58) and GG (OR = 1, 95% CI: 0.80–1.26, P = 0.94) ADIPO − 11377 polymorphism with increased risk of T2D. In addition, the results revealed a trend toward an increased risk of T2D for the SNP + 276 TT genotype (OR = 0.87, 95% CI: 0.77–0.98, P = 0.026) as compared with the GT and GG genotypes. Subgroup analysis by ethnicity indicated significant association between the TT genotype of the SNP + 276 and increased risk of T2D among Europeans. Met-regression demonstrated significant association between the GT genotype of + 276 polymorphism with risk of T2D in male individuals (slope: 0.0006; 95% CI: 0.0002–0.0009; P < 0.001).

Conclusions

Collectively, our findings demonstrated a positive association between ADIPOQ + 276 G > T polymorphism with increased risk of T2D in male individuals with European ethnicity.

Graphical Abstract

Highlights Adiponectin (ADIPOQ) plays an important role in the development of type 2 diabetes and previous studies regarding the association between ADIPOQ polymorphisms and T2D risk reported conflicting results. We performed a meta-analysis to assess the association between two ADIPOQ polymorphisms [− 11377C/G (rs266729), and +276G/T (rs1501299)] and risk for T2D. Odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were pooled to assess the association between four aforementioned polymorphisms and susceptibility to T2D. Overall, there was an association between ADIPOQ +276 G > T with increased T2D risk. Subgroup by ethnicity suggested significant association between +276G/T polymorphism and T2D risk among European ethnicities. Our findings evidence a positive association between ADIPOQ +276 G > T polymorphism with increased risk of T2D in male individuals with European ethnicity.

SUBMITTER: Alimi M 

PROVIDER: S-EPMC8596906 | biostudies-literature |

REPOSITORIES: biostudies-literature