Ontology highlight
ABSTRACT:
SUBMITTER: Kovalenko P
PROVIDER: S-EPMC8597115 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Kovalenko Pavel P Kamal Mohamed A MA Davis John D JD Huniti Nidal N Xu Christine C Bansal Ashish A Shumel Brad B DiCioccio A Thomas AT
Clinical pharmacology in drug development 20210623 11
Population pharmacokinetic (PK) base and covariate analyses were conducted using data from adolescents with moderate-to-severe atopic dermatitis (AD) and children ≥6 to <12 years of age with severe AD. Two phase 3 studies were analyzed (165 adolescents and 241 children on active treatment). A 2-compartment model with linear and Michaelis-Menten elimination and 3 transit compartments describing lag time in absorption was utilized. Weight, albumin, body mass index, and Eczema Area and Severity Ind ...[more]