Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.

ABSTRACT:

Importance

Epidemiologists report a 56% increased risk of veterans with (+) mild traumatic brain injury (mTBI) developing Parkinson's disease (PD) within 12-years post-injury. The most relevant contributors to this high risk of PD in veterans (+) mTBI is unknown. As cognitive problems often precede PD diagnosis, identifying specific domains most involved with mTBI-related PD onset is critical.

Objectives

To discern which cognitive domains underlie the mTBI-PD risk relationship proposed in epidemiology studies.

Design and setting

This exploratory match-controlled, cross-sectional study was conducted in a medical school laboratory from 2017-2020.

Participants

Age- and IQ-matched veterans with (+) and without mTBI, non-veteran healthy controls, and IQ-matched non-

SUBMITTER: Nejtek VA 

PROVIDER: S-EPMC8598036 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature