Faster and less invasive tools to identify patients with ileal colonization by adherent-invasive E. coli in Crohn's disease.

ABSTRACT:

Background and aims

The identification of Crohn's disease (CD)-associated adherent and invasive Escherichia coli (AIEC) is time-consuming and requires ileal biopsies. We aimed to identify a faster and less invasive methods to detect ileal colonization by AIEC in CD patients.

Methods

CD patients requiring ileo-colonoscopy were consecutively enrolled in this prospective multicenter study. Samples from saliva, serum, stools, and ileal biopsies of CD patients were collected.

Results

Among 102 CD patients, the prevalence of AIEC on ileal biopsies was 24.5%. The abundance and global invasive ability of ileal-associated total E. coli were respectively ten-fold (p = 0.0065) and two-fold (p = 0.0007) higher in AIEC-positive (vs. AIEC-negative), while abundance of total E. coli

SUBMITTER: Buisson A 

PROVIDER: S-EPMC8598958 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature