Drug-drug interactions in atrial fibrillation patients receiving direct oral anticoagulants.

ABSTRACT: Polypharmacy is common in patients with atrial fibrillation (AF), making these patients vulnerable to the occurrence of potential drug-drug interactions (DDIs). We assessed the risk of ischemic stroke and major bleeding in the context of concomitant treatment with potential DDIs in patients with AF prescribed direct oral anticoagulants (DOACs). Using the common data model (CDM) based on an electronic health record (EHR) database, we included new users of DOACs from among patients treated for AF between January 2014 and December 2017 (n = 1938). The median age was 72 years, and 61.8% of the patients were males, with 28.2% of the patients having a CHA₂DS₂-VASc score in category 0-1, 49.4% in category 2-3, and 22.4% in category ≥ 4. The CHA₂DS₂-VASc

SUBMITTER: Lee JY 

PROVIDER: S-EPMC8599657 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature