Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction.

ABSTRACT: Complex tissue regeneration is extremely rare among adult mammals. An exception, however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While Acomys species exhibit the remarkable ability to heal complex tissue with minimal scarring, little is known about their cardiac structure and response to cardiac injury. In this study, we first examined baseline Acomys cardiac anatomy and function in comparison with commonly used inbred and outbred laboratory Mus strains (C57BL6 and CFW). While our results demonstrated comparable cardiac anatomy and function between Acomys and Mus, Acomys exhibited a higher percentage of cardiomyocytes displaying distinct characteristics. In response to myocardial infarction, all animals experienced a comparable level of initial cardiac da

SUBMITTER: Peng H 

PROVIDER: S-EPMC8599698 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature