Dataset Information

Functional Connectivity Predicts Individual Development of Inhibitory Control during Adolescence.

ABSTRACT: Derailment of inhibitory control (IC) underlies numerous psychiatric and behavioral disorders, many of which emerge during adolescence. Identifying reliable predictive biomarkers that place the adolescents at elevated risk for future IC deficits can help guide early interventions, yet the scarcity of longitudinal research has hindered the progress. Here, using a large-scale longitudinal dataset in which the same subjects performed a stop signal task during functional magnetic resonance imaging at ages 14 and 19, we tracked their IC development individually and tried to find the brain features predicting their development by constructing prediction models using 14-year-olds' functional connections within a network or between a pair of networks. The participants had distinct between-subject trajectories in their IC development. Of the candidate connections used for prediction, ventral attention-subcortical network interconnections could predict the individual development of IC and formed a prediction model that generalized to previously unseen individuals. Furthermore, we found that connectivity between these two networks was related to substance abuse problems, an IC-deficit related problematic behavior, within 5 years. Our study reveals individual differences in IC development from mid- to late-adolescence and highlights the importance of ventral attention-subcortical network interconnections in predicting future IC development and substance abuse in adolescents.

SUBMITTER: Wang H

PROVIDER: S-EPMC8599716 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Functional Connectivity Predicts Individual Development of Inhibitory Control during Adolescence.

Wang Haiyan H Fan Lingzhong L Song Ming M Liu Bing B Wu Dongya D Jiang Rongtao R Li Jin J Li Ang A Banaschewski Tobias T Bokde Arun L W ALW Quinlan Erin Burke EB Desrivières Sylvane S Flor Herta H Grigis Antoine A Garavan Hugh H Chaarani Bader B Gowland Penny P Heinz Andreas A Ittermann Bernd B Martinot Jean-Luc JL Martinot Marie-Laure Paillère MP Artiges Eric E Nees Frauke F Orfanos Dimitri Papadopoulos DP Poustka Luise L Millenet Sabina S Fröhner Juliane H JH Smolka Michael N MN Walter Henrik H Whelan Robert R Schumann Gunter G Jiang Tianzi T

Cerebral cortex (New York, N.Y. : 1991) 20210301 5

Derailment of inhibitory control (IC) underlies numerous psychiatric and behavioral disorders, many of which emerge during adolescence. Identifying reliable predictive biomarkers that place the adolescents at elevated risk for future IC deficits can help guide early interventions, yet the scarcity of longitudinal research has hindered the progress. Here, using a large-scale longitudinal dataset in which the same subjects performed a stop signal task during functional magnetic resonance imaging a ...[more]

PMID: 33386409

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Project description:IntroductionHeavy drinking (HD) prevalent pattern of alcohol consumption among adolescents, particularly concerning because of their critical vulnerability to the neurotoxic effects of ethanol. Adolescent neurodevelopment is characterized by critical neurobiological changes of the prefrontal, temporal and parietal regions, important for the development of executive control processes, such as inhibitory control (IC). In the present Magnetoencephalography (MEG) study, we aimed to describe the relationship between electrophysiological Functional Connectivity (FC) during an IC task and HD development, as well as its impact on functional neuromaturation.MethodsWe performed a two-year longitudinal protocol with two stages. In the first stage, before the onset of HD, we recorded brain electrophysiological activity from a sample of 67 adolescents (mean age = 14.6 ± 0.7) during an IC task. Alcohol consumption was measured using the AUDIT test and a semi-structured interview. Two years later, in the second stage, 32 of the 67 participants (mean age 16.7 ± 0.7) completed a similar protocol. As for the analysis in the first stage, the source-space FC matrix was calculated, and then, using a cluster-based permutation test (CBPT) based on Spearman's correlation, we calculated the correlation between the FC of each cortical source and the number of standard alcohol units consumed two years later. For the analysis of longitudinal change, we followed a similar approach. We calculated the symmetrized percentage change (SPC) between FC at both stages and performed a CBPT analysis, analyzing the correlation between FC change and the level of alcohol consumed in a regular session.ResultsThe results revealed an association between higher beta-band FC in the prefrontal and temporal regions and higher consumption years later. Longitudinal results showed that greater future alcohol consumption was associated with an exacerbated reduction in the FC of the same areas.DiscussionThese results underline the existence of several brain functional differences prior to alcohol misuse and their impact on functional neuromaturation.

Dataset Information

Functional Connectivity Predicts Individual Development of Inhibitory Control during Adolescence.

Publications

Functional Connectivity Predicts Individual Development of Inhibitory Control during Adolescence.

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