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Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients' Profiles With Oxaliplatin-Induced Peripheral Neuropathy.


ABSTRACT: Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients' characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management.

SUBMITTER: Kerckhove N 

PROVIDER: S-EPMC8599933 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients' Profiles With Oxaliplatin-Induced Peripheral Neuropathy.

Kerckhove Nicolas N   Selvy Marie M   Lambert Céline C   Gonneau Coralie C   Feydel Gabrielle G   Pétorin Caroline C   Vimal-Baguet Agnès A   Melnikov Sergey S   Kullab Sharif S   Hebbar Mohamed M   Bouché Olivier O   Slimano Florian F   Bourgeois Vincent V   Lebrun-Ly Valérie V   Thuillier Frédéric F   Mazard Thibault T   Tavan David D   Benmammar Kheir Eddine KE   Monange Brigitte B   Ramdani Mohamed M   Péré-Vergé Denis D   Huet-Penz Floriane F   Bedjaoui Ahmed A   Genty Florent F   Leyronnas Cécile C   Busserolles Jérôme J   Trévis Sophie S   Pinon Vincent V   Pezet Denis D   Balayssac David D  

Frontiers in pharmacology 20211104


Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters consi  ...[more]

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