Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study.
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ABSTRACT:
SUBMITTER: Hernaez A
PROVIDER: S-EPMC8600658 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
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Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study.
Hernáez Álvaro Á Rogne Tormod T Skåra Karoline H KH Håberg Siri E SE Page Christian M CM Fraser Abigail A Burgess Stephen S Lawlor Deborah A DA Magnus Maria Christine MC
Human reproduction (Oxford, England) 20211101 12
<h4>Study question</h4>What is the association between BMI and subfertility?<h4>Summary answer</h4>We observed a J-shaped relationship between BMI and subfertility in both sexes, when using both a standard multivariable regression and Mendelian randomization (MR) analysis.<h4>What is known already</h4>High BMI in both women and men is associated with subfertility in observational studies and this relationship is further substantiated by a few small randomized controlled trials of weight reductio ...[more]
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Project description:ObjectiveTo investigate the association between smoking and infertility.DesignProspective study.SettingNationwide cohort.Patients28,606 women and 27,096 men with questionnaire and genotype information from the Norwegian Mother, Father, and Child Cohort Study.InterventionSelf-reported information on smoking (having ever smoked [both sexes], age at initiation [women only], cessation [women only], and cigarettes/week in current smokers [both sexes]) was gathered. Genetically predetermined levels or likelihood of presenting these traits were estimated for Mendelian randomization.Main outcome measureInfertility (time-to-pregnancy ≥12 months).ResultsHaving ever smoked was unrelated to infertility in women or men. Higher smoking intensity in women was associated with greater infertility odds (+1 standard deviation [SD, 48 cigarettes/week]: odds ratio [OR]crude, 1.19; 95% confidence interval [CI] 1.11-1.28; ORadjusted 1.12; 95% CI, 1.03-1.21), also after adjusting for the partner's tobacco use. Later smoking initiation (+1 SD [3.2 years]: ORcrude, 0.94; 95% CI, 0.88-0.99; ORadjusted 0.89; 95% CI, 0.84-0.95) and smoking cessation (vs. not quitting: ORcrude, 0.83; 95% CI, 0.75-0.91; ORadjusted, 0.83; 95% CI, 0.75-0.93) were linked to decreased infertility in women. Nevertheless, Mendelian randomization results were not directionally consistent for smoking intensity and cessation and were estimated imprecisely in the 2-sample approach. In men, greater smoking intensity was not robustly associated with infertility in multivariable regression and Mendelian randomization.ConclusionsWe did not find robust evidence of an effect of smoking on infertility. This may be due to a true lack of effect, weak genetic instruments, or other kinds of confounding.
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