Dataset Information

Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.

ABSTRACT:

Introduction

Study of inflammatory cytokines in patients with caustic gastrointestinal tract injury is sketchy. This study investigated the cytokine profiling of patients with caustic substance ingestion, and analyzed the differences between patients with severe and mild injury.

Methods

This prospective, cross-sectional study enrolled 22 patients admitted to Chang Gung Memorial Hospital between March and October 2018. All patients underwent esophagogastroduodenoscopy in 24 hours. Patients were categorized into two subgroups, as mild (<2b, n = 11) or severe (≥2b, n = 11) group.

Results

The neutrophil count was higher in severe than mild group (P = 0.032). Patients in mild and severe groups exhibited significantly higher circulating inflammatory cytokines than healthy control, including interleukin (IL)-2, IL-5, IL-8, IL-9, IL-12, IL-13, interferon-gamma inducible protein-10, macrophage inflammatory protein-1 beta, regulated upon activation, normal T cell expressed and presumably secreted and tumor necrosis factor-alpha. Furthermore, the levels of IL-2 and tumor necrosis factor-alpha were significantly higher in patients with severe group than mild group. Although there was no difference in cumulative survival between both groups (P = 0.147), the severe group received more operations (P = 0.035) and suffered more gastrointestinal complications (P = 0.035) than mild group.

Conclusion

Caustic substance ingestion produces mucosal damages and leads to excessive neutrophils and inflammatory cytokines in peripheral blood.

SUBMITTER: Cheng HT

PROVIDER: S-EPMC8601450 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.

Cheng Hao-Tsai HT Seak Chen-June CJ Cheng Chien-Cheng CC Chen Tsung-Hsing TH Sung Chang-Mu CM Kang Shih-Ching SC Chen Yu-Jhou YJ Ng Chip-Jin CJ Lee Chao-Wei CW Huang Shu-Wei SW Huang Hsin-Chih HC Yen Tzung-Hai TH

PloS one 20211118 11

<h4>Introduction</h4>Study of inflammatory cytokines in patients with caustic gastrointestinal tract injury is sketchy. This study investigated the cytokine profiling of patients with caustic substance ingestion, and analyzed the differences between patients with severe and mild injury.<h4>Methods</h4>This prospective, cross-sectional study enrolled 22 patients admitted to Chang Gung Memorial Hospital between March and October 2018. All patients underwent esophagogastroduodenoscopy in 24 hours. ...[more]

PMID: 34793546

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Dataset Information

Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.

Introduction

Methods

Results

Conclusion

Publications

Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.

Similar Datasets

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