Ontology highlight
ABSTRACT:
SUBMITTER: Anderson EM
PROVIDER: S-EPMC8602448 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Anderson Ethan M EM Lopez Marcelo F MF Kastner Abigail A Mulholland Patrick J PJ Becker Howard C HC Cowan Christopher W CW
Addiction biology 20210519 1
The epigenetic enzyme G9a is a histone methyltransferase that dimethylates lysine 9 on histone H3 (H3K9me2), and in the adult nucleus accumbens (NAc), G9a regulates multiple behaviors associated with substance use disorder. We show here that chronic intermittent ethanol (CIE) exposure in male mice reduced both G9a and H3K9me2 levels in the adult NAc, but not dorsal striatum. Viral-mediated reduction of G9a in the NAc had no effects on baseline volitional ethanol drinking or escalated alcohol dri ...[more]