Ontology highlight
ABSTRACT:
SUBMITTER: Gu Y
PROVIDER: S-EPMC8602706 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Gu Yan Y Chen Yanrong Y Wei Lai L Wu Shuang S Shen Kaicheng K Liu Chengxiang C Dong Yan Y Zhao Yang Y Zhang Yue Y Zhang Chi C Zheng Wenling W He Jiangyi J Wang Yunlong Y Li Yifei Y Zhao Xiaoxin X Wang Hongwei H Tan Jun J Wang Liting L Zhou Qi Q Xie Ganfeng G Liang Houjie H Ou Juanjuan J
Nature communications 20211118 1
Cancer stemness represents a major source of development and progression of colorectal cancer (CRC). c-Met critically contributes to CRC stemness, but how c-Met is activated in CRC remains elusive. We previously identified the lipolytic factor ABHD5 as an important tumour suppressor gene in CRC. Here, we show that loss of ABHD5 promotes c-Met activation to sustain CRC stemness in a non-canonical manner. Mechanistically, we demonstrate that ABHD5 interacts in the cytoplasm with the core subunit o ...[more]