Ontology highlight
ABSTRACT:
SUBMITTER: Zhu L
PROVIDER: S-EPMC8602903 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Zhu Lingyan L Qiu Chao C Dai Lili L Zhang Linxia L Feng Meiqi M Yang Yu Y Qiu Chenli C Zhang Anli A Huang Jun J Wang Ying Y Wan Ying Y Zhao Chen C Wu Hao H Lyu Jianxin J Zhang Xiaoyan X Xu Jianqing J
Frontiers in immunology 20211105
It remains poorly defined whether any human miRNAs play protective roles during HIV infection. Here, focusing on a unique cohort of HIV-infected former blood donors, we identified miR-31 (hsa-miR-31) by comparative miRNA profiling as the only miRNA inversely correlating with disease progression. We further validated this association in two prospective cohort studies. Despite conservation during evolution, hsa-miR-31, unlike its mouse counterpart (mmu-miR-31), was downregulated in human T cell up ...[more]