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Stereoselective Synthesis of Cyclobutanes by Contraction of Pyrrolidines.

ABSTRACT: Here we report a contractive synthesis of multisubstituted cyclobutanes containing multiple stereocenters from readily accessible pyrrolidines using iodonitrene chemistry. Mediated by a nitrogen extrusion process, the stereospecific synthesis of cyclobutanes involves a radical pathway. Unprecedented unsymmetrical spirocyclobutanes were prepared successfully, and a concise, formal synthesis of the cytotoxic natural product piperarborenine B is reported.

SUBMITTER: Hui C

PROVIDER: S-EPMC8603356 | biostudies-literature |

REPOSITORIES: biostudies-literature

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