Ontology highlight
ABSTRACT:
SUBMITTER: Stegh AH
PROVIDER: S-EPMC86037 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Stegh A H AH Herrmann H H Lampel S S Weisenberger D D Andrä K K Seper M M Wiche G G Krammer P H PH Peter M E ME
Molecular and cellular biology 20000801 15
Caspase 8 plays an essential role in the execution of death receptor-mediated apoptosis. To determine the localization of endogenous caspase 8, we used a panel of subunit-specific anti-caspase 8 monoclonal antibodies in confocal immunofluorescence microscopy. In the human breast carcinoma cell line MCF7, caspase 8 predominantly colocalized with and bound to mitochondria. After induction of apoptosis through CD95 or tumor necrosis factor receptor I, active caspase 8 translocated to plectin, a maj ...[more]