Ontology highlight
ABSTRACT:
SUBMITTER: Fumasoni M
PROVIDER: S-EPMC8604288 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Fumasoni Marco M Murray Andrew W AW
PLoS genetics 20211109 11
In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories depend on genomic features by comparing the adaptation in three strains: haploids, diploids, and recombination deficient haploids. In all three, adaptation happens within 1000 generations at rates that are correlated with the initial fitness defect of the ancesto ...[more]