Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD.

ABSTRACT: Attention Deficit-Hyperactivity Disorder (ADHD) is a complex psychiatric and neurodevelopmental disorder that develops during childhood and spans into adulthood. ADHD's aetiology is complex, and evidence about its cause and risk factors is limited. We leveraged genetic data from genome-wide association studies (GWAS) and performed latent causal variable analyses using a hypothesis-free approach to infer causal associations between 1387 complex traits and ADHD. We identified 37 inferred potential causal associations with ADHD risk. Our results reveal that genetic variants associated with iron deficiency anemia (ICD10), obesity, type 2 diabetes, synovitis and tenosynovitis (ICD10), polyarthritis (ICD10), neck or shoulder pain, and substance use in adults display partial genetic causality on

SUBMITTER: Garcia-Marin LM 

PROVIDER: S-EPMC8604995 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature