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Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs.

ABSTRACT: We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG-NH₂-PRX). We expected that PEG-NH₂-PRX provides amino groups to interact with protein drugs on demand because the mobility of amino groups in PEG-NH₂-PRX was high. In fact, PEG-NH₂-PRX formed complexes with protein drugs efficiently compared to PEGylated amino-dextran (PEG-NH₂-DEX), a control material fabricated with a macromolecular backbone polymer. Moreover, PEG-NH₂-PRX markedly improved the stability of antibodies and prolonged the hypoglycemic effects of insulin without loss of bioactivity, compared to PEG-NH₂-DEX. These findings suggest that the supramolecular material, PEG-NH₂-PRX, is a promising reversible PEGylation material for protein drugs compared to macromolecular materials.

SUBMITTER: Utatsu K

PROVIDER: S-EPMC8605344 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs.

Utatsu Kosei K Kogo Tetsuya T Taharabaru Toru T Onodera Risako R Motoyama Keiichi K Higashi Taishi T

Materials today. Bio 20210901

We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG-NH2-PRX). We expected that PEG-NH2-PRX provides amino groups to interact with protein drugs on demand because the mobility of amino groups in PEG-NH2-PRX was high. In fact, PEG-NH2-PRX formed complexes with protein drugs efficiently compared to ...[more]

PMID: 34841242

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