Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs.

ABSTRACT: We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG-NH₂-PRX). We expected that PEG-NH₂-PRX provides amino groups to interact with protein drugs on demand because the mobility of amino groups in PEG-NH₂-PRX was high. In fact, PEG-NH₂-PRX formed complexes with protein drugs efficiently compared to PEGylated amino-dextran (PEG-NH₂-DEX), a control material fabricated with a macromolecular backbone polymer. Moreover, PEG-NH₂-PRX markedly improved the stability of antibodies and prolonged the hypoglycemic effects of insulin without loss of bioactivity, compared to PEG-NH

SUBMITTER: Utatsu K 

PROVIDER: S-EPMC8605344 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature