Ontology highlight
ABSTRACT:
SUBMITTER: Eira J
PROVIDER: S-EPMC8606651 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Eira Jessica J Magalhães Joana J Macedo Nídia N Pero Maria Elena ME Misgeld Thomas T Sousa Mónica M MM Bartolini Francesca F Liz Márcia A MA
Frontiers in cell and developmental biology 20211108
Transthyretin (TTR), a plasma and cerebrospinal fluid protein, increases axon growth and organelle transport in sensory neurons. While neurons extend their axons, the microtubule (MT) cytoskeleton is crucial for the segregation of functional compartments and axonal outgrowth. Herein, we investigated whether TTR promotes axon elongation by modulating MT dynamics. We found that TTR KO mice have an intrinsic increase in dynamic MTs and reduced levels of acetylated α-tubulin in peripheral axons. In ...[more]