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Association between serum PGE₂ levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients.

ABSTRACT:

Background

Mycobacterium tuberculosis that infected apoptotic macrophages is triggered by PGE₂. Apoptosis suppresses the growth of Mycobacterium tuberculosis bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria.

Objective

Analyzing the association between serum PGE₂ levels and the positivity of AFB in the sputum of tuberculosis patients.

Methods

A cross-sectional study was carried out from August 2019-July 2020. Serum PGE₂ levels and AFB levels in sputum were collected from participants. Data analysis used the Chi-square test and Spearman's correlation with p < 0.05.

Results

The average participants' serum PGE₂ levels were 446.37 ± 510.27 pg/ml, with a median value of 216.95 pg/ml. Most participants had normal serum PGE₂ levels (62.9%). Most participants had a high positivity of AFB in sputum (58.1%). Analysis of the association between serum PGE₂ levels and the degree of AFB positivity in sputum obtained r = -0.036 and p-value = 0.780.

Conclusion

There is a weak negative association between serum PGE₂ levels and the degree of AFB positivity in sputum but not statistically significant.

SUBMITTER: Setiawan HW

PROVIDER: S-EPMC8606836 | biostudies-literature |

REPOSITORIES: biostudies-literature

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