Ontology highlight
ABSTRACT:
SUBMITTER: Bonnerot C
PROVIDER: S-EPMC86071 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Bonnerot C C Boeck R R Lapeyre B B
Molecular and cellular biology 20000801 16
We report here the characterization of a bypass suppressor of pab1Delta which leads to a fourfold stabilization of the unstable MFA2 mRNA. Cloning of the wild-type gene for that suppressor reveals that it is identical to PAT1 (YCR077c), a gene whose product was reported to interact with Top2p. PAT1 is not an essential gene, but its deletion leads to a thermosensitive phenotype. Further analysis has shown that PAT1 is allelic with mrt1-3, a mutation previously reported to affect decapping and to ...[more]