Dataset Information

Clinical efficacy and safety of interferon-β-containing regimens in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

The aim of this systematic review and meta-analysis of randomized controlled trials(RCTs) was to investigate the efficacy of interferon (IFN)-β-containing regimens in treating patients with COVID-19.

Methods

PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to 17 July 2021. RCTs comparing the clinical efficacy and safety of IFN-β-containing regimens (study group) to other antiviral treatment options or placebo (control group) in treating patients with COVID-19 were included.

Results

Eight RCTs were included. No significant difference in the 28-day all-cause mortality rate was observed between the study and control groups (OR, 0.74; 95% CI, 0.44-1.24; I² = 51%). The study groups had a lower rate of intensive care unit (ICU) admissions than the control groups (OR 0.58, 95% CI 0.36-0.95; I² = 0%). Furthermore, INF-β was not associated with an increased risk of any adverse event (AE) or serious AE when compared with the control group.

Conclusions

IFN-β does not appear to provide an increased survival benefit in hospitalized patients with COVID-19 but may help reduce the risk of ICU admission. Moreover, IFN-β is a safe agent for use in the treatment of COVID-19.

SUBMITTER: Chen WC

PROVIDER: S-EPMC8607540 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Clinical efficacy and safety of interferon-β-containing regimens in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.

Chen Wang-Chun WC Hsu Chi-Kuei CK Chen Ching-Yi CY Lai Chih-Cheng CC Hung Shun-Hsing SH Lin Wei-Ting WT

Expert review of anti-infective therapy 20211118 5

<h4>Objective</h4>The aim of this systematic review and meta-analysis of randomized controlled trials(RCTs) was to investigate the efficacy of interferon (IFN)-β-containing regimens in treating patients with COVID-19.<h4>Methods</h4>PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to 17 July 2021. RCTs comparing the clinical efficacy and safety of IFN-β-containing regimens (study group) to other antiviral treatment options or pla ...[more]

PMID: 34747295

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Dataset Information

Clinical efficacy and safety of interferon-β-containing regimens in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.

Objective

Methods

Results

Conclusions

Publications

Clinical efficacy and safety of interferon-β-containing regimens in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.

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