Dataset Information

Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.

ABSTRACT:

Aim

Liver cirrhosis and features of muscle or adipose tissues may affect the severity of acute pancreatitis (AP). We aimed to evaluate the impact of body composition parameters and liver cirrhosis on the severity of AP in patients with alcohol-induced AP (AAP).

Methods

Patients with presumed AAP who underwent CT within one week after admission were retrospectively enrolled. L3 sectional areas of abdominal fat and muscle, and mean muscle attenuations (MMAs) were quantified. The presence of liver cirrhosis was determined using clinical and CT findings. Factors potentially associated with moderately severe or severe AP were included in the multivariable logistic regression analysis.

Results

A total of 242 patients (47.0 ± 12.6 years, 215 males) with presumed AAP were included. The mild and moderately severe/severe (MSS) groups included 137 (56.6%) and 105 patients (43.4%), respectively. Patients in the MSS group had higher rates of liver cirrhosis, organ failure, and local complications. Among body composition parameters, mean MMA (33.4 vs 36.8 HU, P<0.0001) and abdominal muscle mass (126.5 vs 135.1 cm2, P = 0.029) were significantly lower in the MSS group. The presence of liver cirrhosis (OR, 4.192; 95% CI, 1.620-10.848) was found to be a significant risk factor for moderately severe or severe AP by multivariable analysis.

Conclusion

The results of this study suggest that liver cirrhosis has a significant impact on the severity of AAP. Of the body composition parameters examined, MMA and abdominal muscle mass showed potential as promising predictors.

SUBMITTER: Jang DK

PROVIDER: S-EPMC8608310 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.

Jang Dong Kee DK Ahn Dong-Won DW Lee Kook Lae KL Kim Byeong Gwan BG Kim Ji Won JW Kim Su Hwan SH Kang Hyoun Woo HW Lee Dong Seok DS Yoon Soon Ho SH Park Sang Joon SJ Jeong Ji Bong JB

PloS one 20211122 11

<h4>Aim</h4>Liver cirrhosis and features of muscle or adipose tissues may affect the severity of acute pancreatitis (AP). We aimed to evaluate the impact of body composition parameters and liver cirrhosis on the severity of AP in patients with alcohol-induced AP (AAP).<h4>Methods</h4>Patients with presumed AAP who underwent CT within one week after admission were retrospectively enrolled. L3 sectional areas of abdominal fat and muscle, and mean muscle attenuations (MMAs) were quantified. The pre ...[more]

PMID: 34807958

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Dataset Information

Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.

Aim

Methods

Results

Conclusion

Publications

Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.

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