Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis.

ABSTRACT: The continuous adherence to the conventional "one target, one drug" paradigm has failed so far to provide effective therapeutic solutions for heterogeneous and multifactorial diseases as amyotrophic lateral sclerosis (ALS), a rare progressive and chronic, debilitating neurological disease for which no cure is available. The present study is aimed at finding innovative solutions and paradigms for therapy in ALS pathogenesis, by exploiting new insights from Network Medicine and drug repurposing strategies. To identify new drug-ALS disease associations, we exploited SAveRUNNER, a recently developed network-based algorithm for drug repurposing, which quantifies the proximity of disease-associated genes to drug targets in the human interactome. We prioritized 403 SAveRUNNER-predicted drugs acco

SUBMITTER: Fiscon G 

PROVIDER: S-EPMC8609089 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature