Diffusion MRI harmonization enables joint-analysis of multicentre data of patients with cerebral small vessel disease.

ABSTRACT:

Objectives

Acquisition-related differences in diffusion magnetic resonance imaging (dMRI) hamper pooling of multicentre data to achieve large sample sizes. A promising solution is to harmonize the raw diffusion signal using rotation invariant spherical harmonic (RISH) features, but this has not been tested in elderly subjects. Here we aimed to establish if RISH harmonization effectively removes acquisition-related differences in multicentre dMRI of elderly subjects with cerebral small vessel disease (SVD), while preserving sensitivity to disease effects.

Methods

Five cohorts of patients with SVD (N = 397) and elderly controls (N = 175) with 3 Tesla MRI on different systems were included. First, to establish effectiveness of harmonization, the RISH method was trained with dat

SUBMITTER: de Brito Robalo BM 

PROVIDER: S-EPMC8609094 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature