Ontology highlight
ABSTRACT:
SUBMITTER: Talross GJS
PROVIDER: S-EPMC8609340 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Talross Gaëlle J S GJS Deryusheva Svetlana S Gall Joseph G JG
Proceedings of the National Academy of Sciences of the United States of America 20211101 45
Small nucleolar (sno)RNAs guide posttranscriptional modifications essential for the biogenesis and function of their target. The majority of snoRNAs in higher eukaryotes are encoded within introns. They are first released from nascent transcripts in the form of a lariat and rapidly targeted by the debranching enzyme and nuclear exonucleases for linearization and further trimming. In this study, we report that some snoRNAs are encoded within unusually stable intronic RNAs. These intronic sequence ...[more]