Ontology highlight
ABSTRACT:
SUBMITTER: Corton JC
PROVIDER: S-EPMC8610372 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Corton J Christopher JC Korunes Katharine L KL Abedini Jaleh J El-Masri Hisham H Brown Jason J Paul-Friedman Katie K Liu Ying Y Martini Cari C He Shihan S Rooney John J
Toxicologic pathology 20201021 7
We hypothesized that typical tissue and clinical chemistry (ClinChem) end points measured in rat toxicity studies exhibit chemical-independent biological thresholds beyond which cancer occurs. Using the rat in vivo TG-GATES study, 75 chemicals were examined across chemical-dose-time comparisons that could be linked to liver tumor outcomes. Thresholds for liver weight to body weight (LW/BW) and 21 serum ClinChem end points were defined as the maximum and minimum values for those exposures that di ...[more]